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OCR: n differentiating ranial diabetes Difficulty is often experience s insipidus. This between primary polydipsia, insipidus and nephrogenic d sic patients have is due to the fact that many p dary to the solute a minor concentrating defect ulla. loss from the renal interstiti in in response to Measurement of plasma vas onship of osmotic stimulation, and the ith urine tion, aids in the endogenous plasma vasopre osmolality after overnight de differentiation of these disor